Nat Sciver scored 90 on her return to the England Women’s team before Charlie Dean took four wickets as Heather Knight’s side began their tour of the West Indies with a massive 142 in the first three one-dayers.
Sciver, who missed the home games against India in September as he prioritized his mental health, hit four fours in his 96-ball knock as England posted 307-7 in Antigua, while Danni Wyatt delivered 68 off 60 balls in his 100th ODI, including three six.
There were also good contributions from opener Tammy Beaumont (33) and new vice-captain Amy Jones (29) while captain Knight, back from hip surgery, scored 16 in his first match since July before England bowled out West Indies for 165 in 40.3 overs. .
The big win gave head coach Jon Lewis a successful start to his tenure, with the former England and Gloucestershire skipper replacing Lisa Keightley.
West Indies reached 84-1 in the 20th over of the chase but then lost wickets in successive overs as Rashada Williams was dismissed by Sciver for 34 and Shemaine Campbelle was dismissed by off-spinner Dean (4-35) for a duck.
England skipper Knight then dismissed Kycia Knight (39) in the 26th over, as West Indies lost their last six wickets for 25 runs as Hayley Matthews (34) was trapped lbw by seamer Lauren Bell.
Dean took the seventh, eighth and ninth wickets, including bowling Cherry-Ann Fraser and a duck, before Sophia Dunkley ended the one-sided game by dismissing Shakera Selman (3).
England’s white-ball tour of the Caribbean continues on Tuesday with the second ODI, and the third on Friday ahead of a five-match T20 series.