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    Home»Business»Pfizer, BioNTech start trial of next-gen COVID-19 vaccine for broader protection
    Business

    Pfizer, BioNTech start trial of next-gen COVID-19 vaccine for broader protection

    Todd LivingstonBy Todd LivingstonNovember 17, 2022No Comments2 Mins Read
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    Row of bottles for the Coronavirus vaccine.  Depth of field.

    -slav-

    Pfizer (NYSE: PFE) and BioNTech (NASDAQ: BNTX) said they initiated a phase 1 trial of a next-generation COVID-19 vaccine aimed at boosting SARS-CoV-2 T cell responses and enhancing immunity to COVID-19.

    The candidate, BNT162b4, has T cells antigen mRNA encoding of novel coronavirus non-spike proteins that are highly conserved among many strains of SARS-CoV-2 and will be evaluated together with the company’s Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine.

    The companies added that the non-spike protein was selected based on BioNTech’s priorities and was developed as a vaccine candidate with the goal of enhancing T-cell immunity and increasing the persistence of immunity against COVID.

    BNT162b4 will be evaluated in a US trial enrolling ~180 healthy people between the ages of 18 and 55 years, who have received at least three doses of the mRNA-based COVID-19 vaccine.

    The pilot study will investigate different dose levels of BNT162b4 given in combination with 30-µg of the company’s Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine and will be compared to the 30-µg administration. dose of Omicron BA.4/BA.5-adapted bivalent COVID vaccine as booster.

    The research is part of the company’s efforts to develop multiple vaccines with the goal of providing a potential vaccine against COVID-19.

    BNTX +0.60% to $165.89 premarket Nov. 17

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    Todd Livingston

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